Observations based on elution of IgG from nephritic kidneys of NZ mice and absorption of the eluted IgG with selected antigens indicate that their immune complex nephritis involves at least two kinds of antigen-antibody complexes. Antibodies reactive with nuclear antigens account for nearly half of the IgG eluted from the kidneys while antibodies reactive with Gross viral antigens make up a significant but lesser amount. Superimposed chronic viral infections affect the nephritis of NZ mice in different ways. LCM and polyoma infections hasten and intensify the antinuclear antibody responses and glomerulonephritis of these mice while LDV infection appears to protect against both antinuclear antibody formation and development of nephritis.
Article|
September 01 1971
PATHOGENESIS OF IMMUNE COMPLEX GLOMERULONEPHRITIS OF NEW ZEALAND MICE
Frank J. Dixon,
Frank J. Dixon
From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037
Search for other works by this author on:
Michael B. A. Oldstone,
Michael B. A. Oldstone
From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037
Search for other works by this author on:
Giorgio Tonietti
Giorgio Tonietti
From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037
Search for other works by this author on:
Frank J. Dixon
From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037
Michael B. A. Oldstone
From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037
Giorgio Tonietti
From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1971 by The Rockefeller University Press
1971
J Exp Med (1971) 134 (3): 65–71.
Citation
Frank J. Dixon, Michael B. A. Oldstone, Giorgio Tonietti; PATHOGENESIS OF IMMUNE COMPLEX GLOMERULONEPHRITIS OF NEW ZEALAND MICE. J Exp Med 1 September 1971; 134 (3): 65–71. doi: https://doi.org/10.1084/jem.134.3.65
Download citation file: