Thymocytes, bone marrow cells, and their derived T and B cell populations were examined for the presence of Ig by the cell surface radioiodination technique. Both IgM and IgG were identified on bone marrow cells. Thymocytes and T cells had no detectable cell surface Ig. Radiolabeling of mixtures of B cells and thymocytes suggest that the method may detect as little as 250 molecules of Ig per cell. Based on these findings, we suggest that the T cell receptor for antigen is not a conventional tetrameric Ig.
CELL SURFACE IMMUNOGLOBULIN : IV. DISTRIBUTION AMONG THYMOCYTES, BONE MARROW CELLS, AND THEIR DERIVED POPULATIONS
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Ellen S. Vitetta, Celso Bianco, Victor Nussenzweig, Jonathan W. Uhr; CELL SURFACE IMMUNOGLOBULIN : IV. DISTRIBUTION AMONG THYMOCYTES, BONE MARROW CELLS, AND THEIR DERIVED POPULATIONS . J Exp Med 1 July 1972; 136 (1): 81–93. doi: https://doi.org/10.1084/jem.136.1.81
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