The transfer of parental (H-2k/k) nonresponder lymphoid cells into heterozygous (H-2k/q) nonresponder recipients at the time of primary challenge with aqueous poly-L(Tyr,Glu)-poly-D,L-Ala-poly-L-Lys [(T,G)-A--L] elicited the production of both IgM and IgG anti-(T,G)-A--L antibody. Normally, the production of IgG anti-(T,G)-A--L antibody is restricted to strains possessing the responder Ir-1 allele. The timing and intensity of the graft-versus-host (GVH) reaction required for this effect were found to be critical. Injection of H-2k/k cells into H-2k/q recipients 1 wk before antigen challenge did not elicit IgG anti-(T,G)-A--L antibody production, and markedly suppressed IgM anti-(T,G)-A--L antibody production. The transfer of alloimmune (H-2q-primed) H-2k/k cells at the time of antigen challenge was also associated with no IgG and little IgM anti-(T,G)-A--L antibody production. These data are consistent with the model that nonresponder thymus-derived lymphocytes (T cells) activated in a GVH reaction can substitute for (T,G)-A--L-reactive T cells to induce a shift from IgM to IgG anti-(T,G)-A--L antibody production.
Article|
November 01 1972
GENETIC CONTROL OF THE IMMUNE RESPONSE : THE EFFECT OF GRAFT-VERSUS-HOST REACTION ON THE ANTIBODY RESPONSE TO POLY-L(TYR,GLU)-POLY-D,L-ALA--POLY-L-LYS IN NONRESPONDER MICE
John C. Ordal,
John C. Ordal
From the Division of Immunology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305
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F. Carl Grumet
F. Carl Grumet
From the Division of Immunology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305
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John C. Ordal
From the Division of Immunology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305
F. Carl Grumet
From the Division of Immunology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305
Received:
May 30 1972
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1972 by The Rockefeller University Press
1972
J Exp Med (1972) 136 (5): 1195–1206.
Article history
Received:
May 30 1972
Citation
John C. Ordal, F. Carl Grumet; GENETIC CONTROL OF THE IMMUNE RESPONSE : THE EFFECT OF GRAFT-VERSUS-HOST REACTION ON THE ANTIBODY RESPONSE TO POLY-L(TYR,GLU)-POLY-D,L-ALA--POLY-L-LYS IN NONRESPONDER MICE . J Exp Med 1 November 1972; 136 (5): 1195–1206. doi: https://doi.org/10.1084/jem.136.5.1195
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