Two H-2-linked autosomal dominant immune response (Ir) genes Ir-IgG and Ir-IgA were demonstrated to be at separate loci. Ir-IgG controls the immune response to IgG (γ2a) myeloma proteins and Ir-IgA the immune response to IgA meyloma proteins. Both genes are associated with the H-2K region specificities of the H-2 chromosome, specifically Ir-IgG with H-2b and Ir-IgA with H-2a. Different recombinants derived from H-2a/H-2b crossovers were examined for their immune responsiveness to BALB/c IgG (γ2a) and IgA myeloma proteins. B10 (H-2b) parental type responded only to IgG; B10.A (H-2a) responded only to IgA. All the recombinants except for B10.A (4R) responded to either IgG or IgA. B10.A (4R), however, responded to both IgG and IgA. This indicated that the crossover event giving rise to B10.A (4R) occurred between the Ir-IgG and Ir-IgA loci.
Article|
November 01 1972
H-2-LINKED IMMUNE RESPONSE (Ir) GENES : INDEPENDENT LOCI FOR Ir-IgG AND Ir-IgA GENES
R. Lieberman,
R. Lieberman
From the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, and The McLaughlin Research Institute, Columbus Hospital, Great Falls, Montana 59401
Search for other works by this author on:
W. E. Paul,
W. E. Paul
From the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, and The McLaughlin Research Institute, Columbus Hospital, Great Falls, Montana 59401
Search for other works by this author on:
W. Humphrey, Jr.,
W. Humphrey, Jr.
From the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, and The McLaughlin Research Institute, Columbus Hospital, Great Falls, Montana 59401
Search for other works by this author on:
J. H. Stimpfling
J. H. Stimpfling
From the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, and The McLaughlin Research Institute, Columbus Hospital, Great Falls, Montana 59401
Search for other works by this author on:
R. Lieberman
From the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, and The McLaughlin Research Institute, Columbus Hospital, Great Falls, Montana 59401
W. E. Paul
From the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, and The McLaughlin Research Institute, Columbus Hospital, Great Falls, Montana 59401
W. Humphrey, Jr.
From the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, and The McLaughlin Research Institute, Columbus Hospital, Great Falls, Montana 59401
J. H. Stimpfling
From the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, and The McLaughlin Research Institute, Columbus Hospital, Great Falls, Montana 59401
Received:
June 07 1972
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1972 by The Rockefeller University Press
1972
J Exp Med (1972) 136 (5): 1231–1240.
Article history
Received:
June 07 1972
Citation
R. Lieberman, W. E. Paul, W. Humphrey, J. H. Stimpfling; H-2-LINKED IMMUNE RESPONSE (Ir) GENES : INDEPENDENT LOCI FOR Ir-IgG AND Ir-IgA GENES . J Exp Med 1 November 1972; 136 (5): 1231–1240. doi: https://doi.org/10.1084/jem.136.5.1231
Download citation file: