The mixed leukocyte culture (MLC) test is an in vitro model of the recognition phase of the homograft response. For the most part, activation in MLC is dependent on differences of the major histocompatibility complex (MHC). Our present studies in the mouse suggest that activation is primarily associated with differences of genetic regions of the MHC other than those which control the serologically defined (H-2) antigens. These differences do not lead to cytotoxic or agglutinating antibody formation despite extensive immunization; we have called these differences lymphocyte-defined (LD) differences. The strongest stimulation in MLC is associated with differences of the Ir region. It is possible that the Ir product is the T cell receptor and that it is this same molecule which can act as the stimulatory agent in MLC. Other possibilities are discussed.
Article|
December 01 1972
SEROLOGICALLY DEFINED AND LYMPHOCYTE-DEFINED COMPONENTS OF THE MAJOR HISTOCOMPATIBILITY COMPLEX IN THE MOUSE
Fritz H. Bach,
Fritz H. Bach
From the Departments of Medical Genetics, Surgery, Pediatrics, and Pharmacology, University of Wisconsin, Madison, Wisconsin 53706, and the Departments of Oral Biology and Human Genetics, University of Michigan, Ann Arbor, Michigan 48104
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Michael B. Widmer,
Michael B. Widmer
From the Departments of Medical Genetics, Surgery, Pediatrics, and Pharmacology, University of Wisconsin, Madison, Wisconsin 53706, and the Departments of Oral Biology and Human Genetics, University of Michigan, Ann Arbor, Michigan 48104
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Marilyn L. Bach,
Marilyn L. Bach
From the Departments of Medical Genetics, Surgery, Pediatrics, and Pharmacology, University of Wisconsin, Madison, Wisconsin 53706, and the Departments of Oral Biology and Human Genetics, University of Michigan, Ann Arbor, Michigan 48104
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Jan Klein
Jan Klein
From the Departments of Medical Genetics, Surgery, Pediatrics, and Pharmacology, University of Wisconsin, Madison, Wisconsin 53706, and the Departments of Oral Biology and Human Genetics, University of Michigan, Ann Arbor, Michigan 48104
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Fritz H. Bach
From the Departments of Medical Genetics, Surgery, Pediatrics, and Pharmacology, University of Wisconsin, Madison, Wisconsin 53706, and the Departments of Oral Biology and Human Genetics, University of Michigan, Ann Arbor, Michigan 48104
Michael B. Widmer
From the Departments of Medical Genetics, Surgery, Pediatrics, and Pharmacology, University of Wisconsin, Madison, Wisconsin 53706, and the Departments of Oral Biology and Human Genetics, University of Michigan, Ann Arbor, Michigan 48104
Marilyn L. Bach
From the Departments of Medical Genetics, Surgery, Pediatrics, and Pharmacology, University of Wisconsin, Madison, Wisconsin 53706, and the Departments of Oral Biology and Human Genetics, University of Michigan, Ann Arbor, Michigan 48104
Jan Klein
From the Departments of Medical Genetics, Surgery, Pediatrics, and Pharmacology, University of Wisconsin, Madison, Wisconsin 53706, and the Departments of Oral Biology and Human Genetics, University of Michigan, Ann Arbor, Michigan 48104
Received:
July 31 1972
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1972 by The Rockefeller University Press.
1972
J Exp Med (1972) 136 (6): 1430–1445.
Article history
Received:
July 31 1972
Citation
Fritz H. Bach, Michael B. Widmer, Marilyn L. Bach, Jan Klein; SEROLOGICALLY DEFINED AND LYMPHOCYTE-DEFINED COMPONENTS OF THE MAJOR HISTOCOMPATIBILITY COMPLEX IN THE MOUSE . J Exp Med 1 December 1972; 136 (6): 1430–1445. doi: https://doi.org/10.1084/jem.136.6.1430
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