The immune response to SRBC was measured in the spleens of adult thymectomized, total body irradiated mice injected with various combinations of thymus and bone marrow cells together with thymic humoral factor (THF). It was found that the number of plaque-forming cells was significantly increased when THF was given in vivo immediately after thymus cell administration or when thymus cells were incubated in THF before injection. On the other hand, bone marrow cells equally treated did not manifest any T cell activity, since THF-treated bone marrow cells were not able to substitute thymus cells in the system used. The results accumulated in the present experiments indicate, therefore, that the target cells for THF activity are thymus cells which acquire a higher T helper cell capacity after THF treatment.
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July 01 1973
STUDIES ON CHARACTERIZATION OF THE LYMPHOID TARGET CELL FOR ACTIVITY OF A THYMUS HUMORAL FACTOR
Varda Rotter,
Varda Rotter
From the Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel
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Amiela Globerson,
Amiela Globerson
From the Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel
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Ichiro Nakamura,
Ichiro Nakamura
From the Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel
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Nathan Trainin
Nathan Trainin
From the Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel
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Varda Rotter
From the Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel
Amiela Globerson
From the Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel
Ichiro Nakamura
From the Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel
Nathan Trainin
From the Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel
Received:
January 30 1973
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1973 by The Rockefeller University Press
1973
J Exp Med (1973) 138 (1): 130–142.
Article history
Received:
January 30 1973
Citation
Varda Rotter, Amiela Globerson, Ichiro Nakamura, Nathan Trainin; STUDIES ON CHARACTERIZATION OF THE LYMPHOID TARGET CELL FOR ACTIVITY OF A THYMUS HUMORAL FACTOR . J Exp Med 1 July 1973; 138 (1): 130–142. doi: https://doi.org/10.1084/jem.138.1.130
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