In the present study it was shown that normal peripheral lymphocytes have two different complement receptors: one for C3b (the immune adherence receptor) and one for C3b subsequent to its cleavage by C3b inactivator. The two receptors are not cross-reactive and were shown by tests with various antisera to be antigenically distinct. Both the immune adherence receptor and the receptor for C3b inactivator-cleaved C3b were found on normal peripheral lymphocytes and on cultured lymphoblastoid cells. In 15 out of 18 chronic lymphatic leukemia patients, the immune adherence receptor was either partially or completely missing from the peripheral lymphocytes, while the lymphocyte receptor for C3b inactivator-cleaved C3b was retained. Normal erythrocytes, on the other hand, were found to have only the immune adherence receptor. Granulocytes from normal peripheral blood appeared to have only a receptor for C3b and did not have a receptor for C3b inactivator-cleaved C3b.
Article|
October 01 1973
TWO DIFFERENT COMPLEMENT RECEPTORS ON HUMAN LYMPHOCYTES : ONE SPECIFIC FOR C3b AND ONE SPECIFIC FOR C3b INACTIVATOR-CLEAVED C3b
Gordon D. Ross,
Gordon D. Ross
From the Department of Medicine, Cornell University Medical College, New York 10021, and the National Jewish Hospital and Research Center, Denver, Colorado 80206
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Margaret J. Polley,
Margaret J. Polley
From the Department of Medicine, Cornell University Medical College, New York 10021, and the National Jewish Hospital and Research Center, Denver, Colorado 80206
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Enrique M. Rabellino,
Enrique M. Rabellino
From the Department of Medicine, Cornell University Medical College, New York 10021, and the National Jewish Hospital and Research Center, Denver, Colorado 80206
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Howard M. Grey
Howard M. Grey
From the Department of Medicine, Cornell University Medical College, New York 10021, and the National Jewish Hospital and Research Center, Denver, Colorado 80206
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Gordon D. Ross
From the Department of Medicine, Cornell University Medical College, New York 10021, and the National Jewish Hospital and Research Center, Denver, Colorado 80206
Margaret J. Polley
From the Department of Medicine, Cornell University Medical College, New York 10021, and the National Jewish Hospital and Research Center, Denver, Colorado 80206
Enrique M. Rabellino
From the Department of Medicine, Cornell University Medical College, New York 10021, and the National Jewish Hospital and Research Center, Denver, Colorado 80206
Howard M. Grey
From the Department of Medicine, Cornell University Medical College, New York 10021, and the National Jewish Hospital and Research Center, Denver, Colorado 80206
Received:
May 10 1973
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1973 by The Rockefeller University Press
1973
J Exp Med (1973) 138 (4): 798–811.
Article history
Received:
May 10 1973
Citation
Gordon D. Ross, Margaret J. Polley, Enrique M. Rabellino, Howard M. Grey; TWO DIFFERENT COMPLEMENT RECEPTORS ON HUMAN LYMPHOCYTES : ONE SPECIFIC FOR C3b AND ONE SPECIFIC FOR C3b INACTIVATOR-CLEAVED C3b . J Exp Med 1 October 1973; 138 (4): 798–811. doi: https://doi.org/10.1084/jem.138.4.798
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