The synthetic single- and double-stranded polynucleotides, poly I, poly C, and poly I·C, were shown to induce thymidine incorporation in six inbred strains of murine spleen cells. This stimulation was shown to be secondary to B-cell activation and not due to contamination of the polynucleotides with bacterial lipopolysaccharide (LPS). The ability of poly I·C to act as a B-cell mitogen, in addition to its behavior as a thymic-independent antigen, suggested that these two phenomena may be related. The similarity of the molecular structure of poly I·C to LPS, a material which also acts as a thymic-independent antigen and a B-cell mitogen, supports the hypothesis that the polyvalent nature of these materials accounts for their functional interaction with murine B cells.
Article|
December 01 1973
SPECIFIC MURINE B-CELL ACTIVATION BY SYNTHETIC SINGLE- AND DOUBLE-STRANDED POLYNUCLEOTIDES
Irwin Scher,
Irwin Scher
From the Division of Rheumatology, Department of Medicine, National Naval Medical Center, and the Clinical Medical Sciences Department, Experimental Immunology Division, Naval Medical Research Institute, Bethesda, Maryland 20014
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Douglas M. Strong,
Douglas M. Strong
From the Division of Rheumatology, Department of Medicine, National Naval Medical Center, and the Clinical Medical Sciences Department, Experimental Immunology Division, Naval Medical Research Institute, Bethesda, Maryland 20014
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Aftab Ahmed,
Aftab Ahmed
From the Division of Rheumatology, Department of Medicine, National Naval Medical Center, and the Clinical Medical Sciences Department, Experimental Immunology Division, Naval Medical Research Institute, Bethesda, Maryland 20014
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Richard C. Knudsen,
Richard C. Knudsen
From the Division of Rheumatology, Department of Medicine, National Naval Medical Center, and the Clinical Medical Sciences Department, Experimental Immunology Division, Naval Medical Research Institute, Bethesda, Maryland 20014
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Kenneth W. Sell
Kenneth W. Sell
From the Division of Rheumatology, Department of Medicine, National Naval Medical Center, and the Clinical Medical Sciences Department, Experimental Immunology Division, Naval Medical Research Institute, Bethesda, Maryland 20014
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Irwin Scher
From the Division of Rheumatology, Department of Medicine, National Naval Medical Center, and the Clinical Medical Sciences Department, Experimental Immunology Division, Naval Medical Research Institute, Bethesda, Maryland 20014
Douglas M. Strong
From the Division of Rheumatology, Department of Medicine, National Naval Medical Center, and the Clinical Medical Sciences Department, Experimental Immunology Division, Naval Medical Research Institute, Bethesda, Maryland 20014
Aftab Ahmed
From the Division of Rheumatology, Department of Medicine, National Naval Medical Center, and the Clinical Medical Sciences Department, Experimental Immunology Division, Naval Medical Research Institute, Bethesda, Maryland 20014
Richard C. Knudsen
From the Division of Rheumatology, Department of Medicine, National Naval Medical Center, and the Clinical Medical Sciences Department, Experimental Immunology Division, Naval Medical Research Institute, Bethesda, Maryland 20014
Kenneth W. Sell
From the Division of Rheumatology, Department of Medicine, National Naval Medical Center, and the Clinical Medical Sciences Department, Experimental Immunology Division, Naval Medical Research Institute, Bethesda, Maryland 20014
Received:
August 08 1973
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1973 by The Rockefeller University Press
1973
J Exp Med (1973) 138 (6): 1545–1563.
Article history
Received:
August 08 1973
Citation
Irwin Scher, Douglas M. Strong, Aftab Ahmed, Richard C. Knudsen, Kenneth W. Sell; SPECIFIC MURINE B-CELL ACTIVATION BY SYNTHETIC SINGLE- AND DOUBLE-STRANDED POLYNUCLEOTIDES . J Exp Med 1 December 1973; 138 (6): 1545–1563. doi: https://doi.org/10.1084/jem.138.6.1545
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