The relationship between cell-mediated immunity to the carrier and the carrier-hapten helper effect was studied in the rat by using three forms of the carrier which differed in their capacity to induce carrier-specific delayed-type hypersensitivity. The three carriers were polymerized flagellin (POL), flagellin (FIN), and acetoacetylated flagellin (AFIN), which induced FIN-specific delayed-type hypersensitivity in the order AFIN > FIN > POL. Helper cells for the anti-DNP antibody responses to a range of DNP-FIN conjugates appeared to be almost inversely related to cell-mediated immunity to the carrier, being in the order POL > FIN ⪖ AFIN. These differences occurred whether the carriers were injected in saline or FCA, but were less pronounced with the heavily DNP-conjugated flagellins.
Brief Definitive Report|
March 01 1974
LACK OF A CORRELATION BETWEEN CELL-MEDIATED IMMUNITY TO THE CARRIER AND THE CARRIER-HAPTEN HELPER EFFECT
F. Y. Liew,
F. Y. Liew
From the Department of Microbiology, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia, 2601
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C. R. Parish
C. R. Parish
From the Department of Microbiology, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia, 2601
Search for other works by this author on:
F. Y. Liew
From the Department of Microbiology, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia, 2601
C. R. Parish
From the Department of Microbiology, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia, 2601
Received:
December 11 1973
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1974 by The Rockefeller University Press
1974
J Exp Med (1974) 139 (3): 779–784.
Article history
Received:
December 11 1973
Citation
F. Y. Liew, C. R. Parish; LACK OF A CORRELATION BETWEEN CELL-MEDIATED IMMUNITY TO THE CARRIER AND THE CARRIER-HAPTEN HELPER EFFECT . J Exp Med 1 March 1974; 139 (3): 779–784. doi: https://doi.org/10.1084/jem.139.3.779
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