Cellular responses in vitro to H-2D region histocompatibility antigens were demonstrated to be under the genetic control of two or three (P = 0.013) independently segregating loci. The H-2 region itself accounts for one of these loci, however, its activity appears to be dependent upon an association with other non-H-2-associated genetic information. The ability to stimulate a response and to respond to that stimulus are two separate genetic functions in certain MLR combinations. The stimuli in our studies were products of the H-2D region and cell donors must differ at that region in order for a response to occur. The control of the level of responses was determined by other genetic material. Differences at these "response loci" were not necessary for the induction of a proliferative response in the mixed lymphocyte cultures.
Article|
April 01 1974
MIXED LYMPHOCYTE CULTURE RESPONSES OF MICE : GENETIC ANALYSIS OF THE RESPONSES TO H-2Dd SPECIFICITIES
Janet M. D. Plate
Janet M. D. Plate
From the Transplantation Unit, General Surgical Services and the Department of Surgery, Harvard Medical School, at the Massachusetts General Hospital, Boston, Massachusetts 02114
Search for other works by this author on:
Janet M. D. Plate
From the Transplantation Unit, General Surgical Services and the Department of Surgery, Harvard Medical School, at the Massachusetts General Hospital, Boston, Massachusetts 02114
Received:
January 01 1974
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1974 by The Rockefeller University Press
1974
J Exp Med (1974) 139 (4): 851–861.
Article history
Received:
January 01 1974
Citation
Janet M. D. Plate; MIXED LYMPHOCYTE CULTURE RESPONSES OF MICE : GENETIC ANALYSIS OF THE RESPONSES TO H-2Dd SPECIFICITIES . J Exp Med 1 April 1974; 139 (4): 851–861. doi: https://doi.org/10.1084/jem.139.4.851
Download citation file: