Serum IgM immunoglobulin levels and antibody responses to an optimally immunogenic dose of Type III pneumococcal polysaccharide (SSS-III) were assessed for F1, F2, and backcross progeny derived from crosses between high responding BALB/cAnN (B) and low responding CBA/HN (C) mice. The results obtained confirmed our original hypothesis, namely, that a major component, present on the X chromosome, governs the ability to respond to SSS-III in a decisive manner. Although all low responding C mice had low IgM levels, both intermediate and high responders had high IgM levels of the same magnitude. Treatment with bacterial lipopolysaccharides (LPS) resulted in a significant increase in the IgM levels of low responding C mice. While the IgM levels attained were similar to those of high responding B mice, not given LPS, no antibody specific for LPS appeared to be produced. These findings suggest that C mice are unable to make an IgM antibody response to SSS-III and other polysaccharide antigens, despite the fact that they possess the capacity to synthesize normal amounts of IgM immunoglobulin.
Article|
June 01 1974
GENETIC CONTROL OF THE ANTIBODY RESPONSE TO TYPE III PNEUMOCOCCAL POLYSACCHARIDE IN MICE : II. RELATIONSHIP BETWEEN IgM IMMUNOGLOBULIN LEVELS AND THE ABILITY TO GIVE AN IgM ANTIBODY RESPONSE
Diana F. Amsbaugh,
Diana F. Amsbaugh
From the Laboratory of Microbial Immunity and Laboratory of Microbiology, National Institute of Allergy and Infectious Diseases, and the Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014
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Carl T. Hansen,
Carl T. Hansen
From the Laboratory of Microbial Immunity and Laboratory of Microbiology, National Institute of Allergy and Infectious Diseases, and the Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014
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Benjamin Prescott,
Benjamin Prescott
From the Laboratory of Microbial Immunity and Laboratory of Microbiology, National Institute of Allergy and Infectious Diseases, and the Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014
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Philip W. Stashak,
Philip W. Stashak
From the Laboratory of Microbial Immunity and Laboratory of Microbiology, National Institute of Allergy and Infectious Diseases, and the Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014
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Richard Asofsky,
Richard Asofsky
From the Laboratory of Microbial Immunity and Laboratory of Microbiology, National Institute of Allergy and Infectious Diseases, and the Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014
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Phillip J. Baker
Phillip J. Baker
From the Laboratory of Microbial Immunity and Laboratory of Microbiology, National Institute of Allergy and Infectious Diseases, and the Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014
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Diana F. Amsbaugh
From the Laboratory of Microbial Immunity and Laboratory of Microbiology, National Institute of Allergy and Infectious Diseases, and the Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014
Carl T. Hansen
From the Laboratory of Microbial Immunity and Laboratory of Microbiology, National Institute of Allergy and Infectious Diseases, and the Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014
Benjamin Prescott
From the Laboratory of Microbial Immunity and Laboratory of Microbiology, National Institute of Allergy and Infectious Diseases, and the Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014
Philip W. Stashak
From the Laboratory of Microbial Immunity and Laboratory of Microbiology, National Institute of Allergy and Infectious Diseases, and the Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014
Richard Asofsky
From the Laboratory of Microbial Immunity and Laboratory of Microbiology, National Institute of Allergy and Infectious Diseases, and the Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014
Phillip J. Baker
From the Laboratory of Microbial Immunity and Laboratory of Microbiology, National Institute of Allergy and Infectious Diseases, and the Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014
Received:
January 28 1974
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1974 by The Rockefeller University Press
1974
J Exp Med (1974) 139 (6): 1499–1512.
Article history
Received:
January 28 1974
Citation
Diana F. Amsbaugh, Carl T. Hansen, Benjamin Prescott, Philip W. Stashak, Richard Asofsky, Phillip J. Baker; GENETIC CONTROL OF THE ANTIBODY RESPONSE TO TYPE III PNEUMOCOCCAL POLYSACCHARIDE IN MICE : II. RELATIONSHIP BETWEEN IgM IMMUNOGLOBULIN LEVELS AND THE ABILITY TO GIVE AN IgM ANTIBODY RESPONSE . J Exp Med 1 June 1974; 139 (6): 1499–1512. doi: https://doi.org/10.1084/jem.139.6.1499
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