Selected populations of thymus-derived (T) rat lymphocytes having specific immunological reactivity to chosen histocompatibility (H) alloantigens are found among the cellular products of the mixed lymphocyte interaction (MLI). Such specific selection seems to depend on (a) the antigen-induced proliferation of specific H antigen reactive cells (HARC), and (b) the disappearance of nonreactive cells from the cultures. When the surviving cells from this lymphocyte-antigen interaction are transferred into thymectomized, X-irradiated, marrow-reconstituted syngeneic recipients (B rats) which lack detectable T-lymphocyte functions, the lymphocyte populations subsequently recovered from the hosts possess the capacity to react in the MLI and in the graft-vs.-host (GVH) reaction, and the reactions have specificity for the original priming alloantigens. In addition, these findings identify the cell that reacts in the MLI with the GVH reactive cell.
Article|
September 01 1974
SPECIFIC POSITIVE SELECTION OF LYMPHOCYTES REACTIVE TO STRONG HISTOCOMPATIBILITY ANTIGENS
Jonathan C. Howard,
Jonathan C. Howard
From the Immunobiology Research Unit, Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19174
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Darcy B. Wilson
Darcy B. Wilson
From the Immunobiology Research Unit, Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19174
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Jonathan C. Howard
From the Immunobiology Research Unit, Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19174
Darcy B. Wilson
From the Immunobiology Research Unit, Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19174
Received:
October 28 1973
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1974 by The Rockefeller University Press
1974
J Exp Med (1974) 140 (3): 660–672.
Article history
Received:
October 28 1973
Citation
Jonathan C. Howard, Darcy B. Wilson; SPECIFIC POSITIVE SELECTION OF LYMPHOCYTES REACTIVE TO STRONG HISTOCOMPATIBILITY ANTIGENS . J Exp Med 1 September 1974; 140 (3): 660–672. doi: https://doi.org/10.1084/jem.140.3.660
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