CHARACTERIZATION OF A NEW INTRA-H-2 RECOMBINANT : SEPARATION OF THE Ir-RE AND Ir-GLT GENES

This report characterizes the intra-H-2 crossover in the D2.GD mouse strain. Recombination occurred within the I region between the immune response (Ir) gene controlling immune responsiveness to ragweed extract (RE). Ir-RE, and the Ir gene governing responsiveness to the random linear terpolymers of glutamic acid and lysine with either tyrosine or pheylalanine (Ir-GLT and Ir-GLϕ). The Ir-RE gene was tentatively located in the Ir-1A subregion and the Ir-GLT and Ir-GLϕ gene(s) tentatively placed in the Ir-1B subregion. The importance of this recombinant strain to further studies on the fine structure of the I region is discussed.