The concentration of the amyloid AA-related serum protein (SAA) was markedly increased after endotoxin injections in mink, mouse, rabbit, and man. It was particularly studied during the development of endotoxin-induced amyloidosis of the mink. Protein SAA was markedly elevated in all mink 24 h after the first endotoxin injection but had fallen to relatively low levels before the onset of amyloidosis at about 4 wk. These results are consistent with SAA being a circulating precursor of the amyloid fibril protein, AA. However, both proteins may be derived by proteolysis from a common precursor.
Article| March 01 1976
Amyloid-related serum protein SAA in endotoxin-induced amyloidosis of the mink.
R F Anders
J B Natvig
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1976) 143 (3): 678–683.
R F Anders, K Nordstoga, J B Natvig, G Husby; Amyloid-related serum protein SAA in endotoxin-induced amyloidosis of the mink.. J Exp Med 1 March 1976; 143 (3): 678–683. doi: https://doi.org/10.1084/jem.143.3.678
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