The possibility that the two complementing alpha- and beta-Ir-GLphi genes are independently responsible for controlling events in T lymphocytes and B lymphocytes, respectively, has been tested in double adoptive transfer experiments utilizing cells from appropriate inbred strains of mice. The results of these studies show that the functions of T lymphocytes and B lymphocytes and the cooperative interactions between T and B cells require the presence of both alpha- and beta-genes in each respective cell type. Moreover, evidence has been obtained in these studies that indicates a preference for the alpha- and beta-Ir-GLphi genes in the cis position to obtain the most effective T-B-cell interactions. The possible implications of these findings are discussed.
Article| April 01 1976
Control of t-lymphocyte and B-lymphocyte activation by two complementing Ir-GLphi immune response genes.
D H Katz
M E Dorf
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1976) 143 (4): 906–918.
D H Katz, M E Dorf, B Benacerraf; Control of t-lymphocyte and B-lymphocyte activation by two complementing Ir-GLphi immune response genes.. J Exp Med 1 April 1976; 143 (4): 906–918. doi: https://doi.org/10.1084/jem.143.4.906
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