The Ly and Ia phenotypes of T lymphocytes involved in different functions were characterized by the use of specific antisera. T cells responsible for delayed-type hypersensitivity (DTH) and for helper functions were found to be Ly-1+,2- in contrast to cytotoxic T cells and T cells responsible for suppression of antibody responses which were Ly-1-,2+. Unlike some primed helper cells, T cells involved in DTH were Ia-. Suppressor cells in the system were Ia+.
Ly and Ia antigen phenotypes of T cells involved in delayed-type hypersensitivity and in suppression.
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M A Vadas, J F Miller, I F McKenzie, S E Chism, F W Shen, E A Boyse, J R Gamble, A M Whitelaw; Ly and Ia antigen phenotypes of T cells involved in delayed-type hypersensitivity and in suppression.. J Exp Med 1 July 1976; 144 (1): 10–19. doi: https://doi.org/10.1084/jem.144.1.10
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