The Fc receptors of thymic and splenic T lymphocytes were detected using indirect immunofluorescence and soluble antigen-antibody complexes. 10-20% of thymocytes and 40-50% of Thy-1-positive splenic lymphocytes bound antigen-complexed Ig. The binding to thymocytes was partially inhibited (45-74%) by antibodies against antigens determined by the I region of the H-2 complex, but not by antibodies against K- or D-region antigens or Thy-1 antigen. The inhibition did not require the Fc portion of the inhibiting antibody. These results provide evidence that Ia antigens and the Fc receptors of some T lymphocytes are associated, and that the populations of T cells which bear these moieties at least partially overlap.
Article| July 01 1976
Association between Ia antigens and the Fc receptors of certain T lymphocytes.
H B Dickler
R D Arbeit
P A Henkart
D H Sachs
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1976) 144 (1): 282–287.
H B Dickler, R D Arbeit, P A Henkart, D H Sachs; Association between Ia antigens and the Fc receptors of certain T lymphocytes.. J Exp Med 1 July 1976; 144 (1): 282–287. doi: https://doi.org/10.1084/jem.144.1.282
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