Splenic and peritoneal macrophages from mice treated with Corynebacterium parvum enhanced the antibody response in vitro of normal nonadherent spleen cells to SRBC, but not to DNP-POL. This enhancement was dependent on the dose and time of administration of C. parvum and could be abrogated by pretreatment with carrageenan. Macrophages from T-cell-depleted mice failed to enhance the response, but this ability was restored if the mice had been reconstituted with purified T lymphocytes. Macrophages that are activated by C. parvum are a resident nondividing population. It is postulated that activated macrophages, capable of enhancing antibody responses to T-cell-dependent antigens, arise through a cell-mediated reaction to C. parvum.
Article| January 01 1977
The adjuvant effect of Corynebacterium parvum: T-cell dependence of macrophage activation.
V S Sljivić
S R Watson
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1977) 145 (1): 45–57.
V S Sljivić, S R Watson; The adjuvant effect of Corynebacterium parvum: T-cell dependence of macrophage activation.. J Exp Med 1 January 1977; 145 (1): 45–57. doi: https://doi.org/10.1084/jem.145.1.45
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