The in vitro synthesis of allotypes of b4/b5 offspring obtained from b4/b4 mothers immunized against paternal allotype b5/b5 was studied in comparison to similar offspring that had escaped from suppression and normal heterozygous b4/b5 rabbits. Nocardia water-soluble mitogen-a rabbit B-cell mitogen which is known to induce the differentiation of small lymphocytes into plasma cells and polyclonal activation of Ig, was able to break in vitro the allotypic suppression induced in vivo.
Article| September 01 1977
Release from maternally-induced allotypic suppression in rabbit by Nocardia water-soluble mitogen.
P A Cazenave
Online Issn: 1540-9538
Print Issn: 0022-1007
J Exp Med (1977) 146 (3): 881–886.
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C Bona, P A Cazenave; Release from maternally-induced allotypic suppression in rabbit by Nocardia water-soluble mitogen.. J Exp Med 1 September 1977; 146 (3): 881–886. doi: https://doi.org/10.1084/jem.146.3.881
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