Synthesis of H-2 antigens by preimplantation mouse embryos is first detectable at the late blastocyst stage. These antigens were detected using immune precipitation assays of extracts of embryos labeled by incorporation of radioactive amino acids but not by surface iodination. Experiments using isolated inner cell massess and trophoblast vesicles indicate that it is the cells of the inner cell mass that synthesize these antigens. H-2 antigens were not detected in either early blastocysts or at earlier cleavage stages.
Article| October 01 1977
Synthesis and distribution of H-2 antigens in preimplantation mouse embryos.
C G Webb
W E Gall
G M Edelman
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1977) 146 (4): 923–932.
C G Webb, W E Gall, G M Edelman; Synthesis and distribution of H-2 antigens in preimplantation mouse embryos.. J Exp Med 1 October 1977; 146 (4): 923–932. doi: https://doi.org/10.1084/jem.146.4.923
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