Susceptibility to leukemia induction in mice by skin painting with 3-methylcholanthrene (MCA) is strain-specific, occurring only in strains relatively resistant to MCA-induced skin tumors. The Ah locus, which has a dominant allele (Ahb) for inducibility of the aryl hydrocarbon hydroxylase (AHH) enzyme system and a recessive allele (Ahd) for noninducibility, appears to be the major determinant of this trait. MCA-painted mice of strains and crosses carrying the Ahb allele usually show a high incidence of skin tumors (papillomas which may evolve into malignant tumors) and little or no leukemia, whereas in mice homozygous for the Ahd allele the treatment usually induces a high incidence of leukemia and few or no skin tumors. Among mice of a segregating backcross generation including both Ahb/Ahd heterozygotes and Ahd homozygotes, the occurrence of skin tumors was correlated directly with AHH inducibility and inversely with the leukemic response. Mice of Ahb strains with a high level of endogenous murine leukemia (MuLV) expression (C58, PL) show a much weaker skin tumor response than expected but no increase in leukemia incidence, and this observation tends to confirm the previous finding that MuLV infection of mice of low-MuLV strains results in reduced susceptibility to MCA tumorigenesis.
Article|
February 01 1978
The genetic basis of susceptibility to leukemia induction in mice by 3-methylcholanthrene applied percutaneously.
M L Duran-Reynals
F Lilly
A Bosch
K J Blank
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1978) 147 (2): 459–469.
Citation
M L Duran-Reynals, F Lilly, A Bosch, K J Blank; The genetic basis of susceptibility to leukemia induction in mice by 3-methylcholanthrene applied percutaneously.. J Exp Med 1 February 1978; 147 (2): 459–469. doi: https://doi.org/10.1084/jem.147.2.459
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