XX cells from XX/XY hemopoietic chimeras do not express male determinants in a way to render them either stimulators or targets for male-specific cytotoxic lymphocytes. XX- but not XY-responder T cells from chimeras can be activated to lyse allogeneic male target cells; T cells from normal XX mice depleted of alloreactive T cells, however, cannot be sensitized to lyse allogeneic XY targets. The results imply that T cells recognize the Y-antigen and H-2 as distinct entities, and that in chimeras, they acquire the potential to react against allogeneic XY cells.
Article| April 01 1978
Cytotoxic T cells recognize male antigen and H-2 as distinct entities.
H von Boehmer
Online Issn: 1540-9538
Print Issn: 0022-1007
J Exp Med (1978) 147 (4): 1291–1295.
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H von Boehmer, W Haas, H Pohlit; Cytotoxic T cells recognize male antigen and H-2 as distinct entities.. J Exp Med 1 April 1978; 147 (4): 1291–1295. doi: https://doi.org/10.1084/jem.147.4.1291
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