The H-Y-specific cytotoxic T-cell response requires helper cells: cells from bone marrow chimeras B6 X CBA leads to B6, B6 X CBA leads to B10.A (5R), or B6 X CBA leads to CBA are each unable to respond to H-2k male cells. If, however, cells from B6 X CBA leads to B6 or B6 X CBA leads to B10.A (5R) chimeras are adoptively transferred together with cells from B6 X CBA leads to CBA chimeras, H-Y-specific CTL restricted to H-2k can be obtained. Thus, cells from B6 X CBA leads to B6 or B6 X CBA leads to B10.,A (5R) chimeras (restricted to the left end of the H-2b haplotype) can help CTL precursors from B6 X CBA leads to CBA chimeras (restricted to H-2k). The two classes of T cells required for the CTL response to H-Y antigen are controlled by different IR genes. All H-Y-specific CTL obtained from chimeras B6 + CBA leads to B6 X CBA were found to be of B6 origin. This suggests that CTL or their precursors must express antigens encoded in the left end of the H-2b haplotype for interaction with helper cells.
Article| November 01 1979
Distinct Ir genes for helper and killer cells in the cytotoxic response to H-Y antigen.
H von Boehmer
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1979) 150 (5): 1134–1142.
H von Boehmer, W Haas; Distinct Ir genes for helper and killer cells in the cytotoxic response to H-Y antigen.. J Exp Med 1 November 1979; 150 (5): 1134–1142. doi: https://doi.org/10.1084/jem.150.5.1134
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