The B10.D2 cytolytic T lymphocyte (CTL) receptor repertoire specific for the H-2Kb alloantigen has been studied by determining the reactivity patterns of monoclonal CTL against a panel of seven different H-2Kb mutants. The repertoire is extremely diverse and contains a minimum of approximately 50 different specificities against unique antigenic determinants on the H-2Kb molecule. Each specificity appears at a maximum frequency of 1 in 18,000 CTL precursors. These studies have also served to dissect the antigenic composition of the H-2Kb molecule. Very few CTL clonotypes share recognition of all the mutants, thereby indicating the lack of conservation of a b-type antigenic region. In addition, the degree to which each mutant shares antigenic determinants with the standard H-2Kb molecule has been determined.
Article| June 01 1980
Dissection of the B10.D2 anti-H-2Kb cytolytic T lymphocyte receptor repertoire.
L A Sherman
Online Issn: 1540-9538
Print Issn: 0022-1007
J Exp Med (1980) 151 (6): 1386–1397.
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L A Sherman; Dissection of the B10.D2 anti-H-2Kb cytolytic T lymphocyte receptor repertoire.. J Exp Med 1 June 1980; 151 (6): 1386–1397. doi: https://doi.org/10.1084/jem.151.6.1386
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