A single mendelian gene was identified for induction of the endogenous xenotropic murine leukemia virus in five mouse strains (C57BL/10, C57L, C57BR, AKR, and BALB/c). This locus, designated Bxv-1, mapped to the same site on chromosome 1 in all strains: Id-1-Pep-3-[Bxv-1-Lp]. Thus, inducibility loci for xenotropic virus are more limited in number and chromosomal distribution than ecotropic inducibility loci. Virus expression in mice with Bxv-1 was induced by treatment of fibroblasts with 5-iododeoxyuridine or by exposure of spleen cells to a B cell mitogen, bacterial lipopolysaccharide. An analysis of the hamster X mouse somatic cell hybrids indicated that chromosome 1, alone, was sufficient for virus induction.
Article| July 01 1980
Genetic mapping of xenotropic murine leukemia virus-inducing loci in five mouse strains.
C A Kozak
W P Rowe
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1980) 152 (1): 219–228.
C A Kozak, W P Rowe; Genetic mapping of xenotropic murine leukemia virus-inducing loci in five mouse strains.. J Exp Med 1 July 1980; 152 (1): 219–228. doi: https://doi.org/10.1084/jem.152.1.219
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