Delayed hypersensitivity reaction in mice was commonly enhanced with various anti-cancer agents administered as single or intermittent high doses but not consecutive divided doses. The effect of anti-cancer agents on the delayed hypersensitivity reaction was thought to be due to elimination of suppressor T cell activity.
Enhancement of delayed hypersensitivity reaction with varieties of anti-cancer drugs. A common biological phenomenon.
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M Goto, A Mitsuoka, M Sugiyama, M Kitano; Enhancement of delayed hypersensitivity reaction with varieties of anti-cancer drugs. A common biological phenomenon.. J Exp Med 1 July 1981; 154 (1): 204–209. doi: https://doi.org/10.1084/jem.154.1.204
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