A variety of invasive stimuli have been shown to induce hyperlipidemia due to impaired removal of triglyceride from the circulation. The mechanism by which endotoxin induces a deficiency in the activity of the key enzyme of triglyceride metabolism, lipoprotein lipase (LPL), has been studied. In C3H/HeN (endotoxin-sensitive) mice, LPL activity in adipose tissue was markedly suppressed 16 h after endotoxin administration. In contrast, the endotoxin-resistant C3H/HeJ mice were less sensitive to the suppressive effect of endotoxin on LPL activity. After endotoxin administration, a transferable factor had been detected in the blood of C3H/HeN mice 2 h after the injection of endotoxin that causes a suppression of adipose tissue LPL activity in C3H/HeJ mice as well as in C3H/HeN mice. Conditioned medium from the cultures of peritoneal exudate cells of C3H/HeN mice incubated in endotoxin also suppresses adipose tissue LPL in C3H/HeJ mice. These studies demonstrate that exudate cells produce a humoral factor in response to endotoxin, which suppresses adipose tissue LPL.
Article| September 01 1981
Studies of endotoxin-induced decrease in lipoprotein lipase activity.
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1981) 154 (3): 631–639.
M Kawakami, A Cerami; Studies of endotoxin-induced decrease in lipoprotein lipase activity.. J Exp Med 1 September 1981; 154 (3): 631–639. doi: https://doi.org/10.1084/jem.154.3.631
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