Rats immunized with renal tubular antigens were protected from the development of interstitial nephritis by pretreatment with tubular antigen-reactive T lymphoblasts. Protected animals developed anti-idiotypic antibodies against idiotypes primarily within the antigen-binding region of monoclonal antitubular basement membrane antibodies. These studies extend the concept of auto-anti-idiotypic regulation to autoimmune disease, and they also provide an experimental basis for further efforts to develop biologically relevant mechanisms for attenuating the expression of other kidney diseases.
Article| January 01 1982
Suppression of interstitial nephritis by auto-anti-idiotypic immunity.
E G Neilson
Online Issn: 1540-9538
Print Issn: 0022-1007
J Exp Med (1982) 155 (1): 179–189.
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E G Neilson, M Phillips; Suppression of interstitial nephritis by auto-anti-idiotypic immunity.. J Exp Med 1 January 1982; 155 (1): 179–189. doi: https://doi.org/10.1084/jem.155.1.179
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