Mice were bred that simultaneously expressed the mutations nude and x-linked immune deficiency (xid). These doubly deficient animals had less than 10% of normal serum immunoglobulin levels. Their spleen cells did not respond to thymus-independent antigens in vitro nor did they respond to lipopolysaccharide. There was a virtual absence of cells with surface mu, kappa, or lambda 1, as detected by fluorescence. Sections of lymphoid organs revealed an absence of primary B cell follicles. Taken together, these results indicate a lack of mature B cells in nude xid mice. The possibility is considered that mature B cells belong to two subpopulations representing two lineages, one controlled by alleles at the xid locus and the other by alleles at the nude locus.
Article| March 01 1982
Lack of mature B cells in nude mice with X-linked immune deficiency.
H H Wortis
Online Issn: 1540-9538
Print Issn: 0022-1007
J Exp Med (1982) 155 (3): 903–913.
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H H Wortis, L Burkly, D Hughes, S Roschelle, G Waneck; Lack of mature B cells in nude mice with X-linked immune deficiency.. J Exp Med 1 March 1982; 155 (3): 903–913. doi: https://doi.org/10.1084/jem.155.3.903
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