We have found that sera from humans with Chagas' disease and Rhesus monkeys infected with Trypanosoma cruzi contain IgM and IgG antibodies, which react with structures in a variety of connective tissues. These antibodies react with laminin but not with various other purified connective tissue components like collagen types I, III, IV, and V, fibronectin, heparan sulfate (BM-1) proteoglycan, or chondronectin. The tissue-reacting antibodies were isolated by absorption to a laminin-Sepharose column. The bound fraction contained all the tissue-reacting antibodies. These antibodies strongly stained trypomastigotes and amastigotes, but weakly stained epimastigotes. These studies show that sera from T. cruzi-infected primates contain antilaminin antibodies, which may be produced by those host in response to a laminin-like molecule present in the parasite.
Antibodies to laminin in Chagas' disease.
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A Szarfman, V P Terranova, S I Rennard, J M Foidart, M de Fatima Lima, J I Scheinman, G R Martin; Antibodies to laminin in Chagas' disease.. J Exp Med 1 April 1982; 155 (4): 1161–1171. doi: https://doi.org/10.1084/jem.155.4.1161
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