Experimental murine listeriosis was used as a model to investigate the immunological basis for the age-associated decline in antimicrobial immunity. The reduced capacity of protective T cells from Listeria-immune senescent mice to adoptively immunize normal syngeneic recipients could not be attributed to inhibition of their activity by suppressor cells. Radiolabeled enriched splenic T cells from Listeria-immune young or senescent donors exhibited an identical distribution pattern after an intravenous infusion into young recipients. Moreover, cells from Listeria-immune young donors showed markedly greater protective capacity than cells from senescent immune donors whether the cells were transferred to young or senescent recipients. Dose-response analysis of protective T cells revealed that in response to immunizing infection (a) senescent mice generated 10-fold fewer protective T cells, and (b) protective T cells from senescent mice were 100-fold less efficient than cells from young mice.
Aging and antimicrobial immunity. Lowered efficiency of protective T cells as a contributing factor for the decreased resistance of senescent mice to listeriosis.
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P J Patel; Aging and antimicrobial immunity. Lowered efficiency of protective T cells as a contributing factor for the decreased resistance of senescent mice to listeriosis.. J Exp Med 1 June 1982; 155 (6): 1870–1875. doi: https://doi.org/10.1084/jem.155.6.1870
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