Evidence is presented that interleukin 2 (IL-2) is not sufficient to cause the differentiation of primary cytotoxic T lymphocytes (CTL). Sources of IL-2 were compared for their ability to cause proliferation as well as differentiation into CTL. Whereas all factors caused proliferation, only the crude Con A supernatant had cytotoxic T cell differentiation factor (CTDF) activity. Furthermore, factors absorbed with an IL-2-dependent cell line to remove IL-2 still retained CTDF activity. Thus, IL-2 functions to cause clonal expansion of CTL precursors preactivated by antigen or mitogen, but for their differentiation into CTL, an additional factor is required, here called CTDF.
Dissection of the proliferative and differentiative signals controlling murine cytotoxic T lymphocyte responses.
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H Wagner, C Hardt, B T Rouse, M Röllinghoff, P Scheurich, K Pfizenmaier; Dissection of the proliferative and differentiative signals controlling murine cytotoxic T lymphocyte responses.. J Exp Med 1 June 1982; 155 (6): 1876–1881. doi: https://doi.org/10.1084/jem.155.6.1876
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