We report here a class of helper cell-independent cytotoxic T cell (HITc) clones in man that can proliferate in response to antigenic stimulation as well as mediate cytotoxicity. HITc appear to be rare among clones derived from primary in vitro allosensitized culture, but constitute the majority of clones derived from cells sensitized to autologous Epstein-Barr virus-transformed lymphoblastoid cell lines. The implications of the derivation and function of HITc clones are discussed.
Article| December 01 1982
Helper cell-independent cytotoxic clones in man.
S L Wee
L K Chen
F H Bach
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1982) 156 (6): 1854–1859.
S L Wee, L K Chen, G Strassmann, F H Bach; Helper cell-independent cytotoxic clones in man.. J Exp Med 1 December 1982; 156 (6): 1854–1859. doi: https://doi.org/10.1084/jem.156.6.1854
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