Mta-specific cytotoxic T lymphocyte (CTL) can be generated in primary cultures of (NZB X B10.D2)F1 spleen cells with H-2-compatible BALB/c stimulator cells. The CTL lyse reciprocal Mta+ (B10.D2 X NZB)F1 as well as H-2-disparate targets, such as B10, B6, and B6-Tlaa; they do not lyse targets from NZB or any F1 hybrid of an NZB mother. The lysis of 51Cr-labeled B10 targets is completely inhibited by unlabeled targets from Mta+ (B10.D2 X NZB)F1, but not from the reciprocal Mta- F1, thus demonstrating H-2-unrestricted lysis of Mta.
Article| December 01 1982
Primary cell-mediated lympholysis response to a maternally transmitted antigen.
R Smith, 3rd
D P Huston
R R Rich
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1982) 156 (6): 1866–1871.
R Smith, D P Huston, R R Rich; Primary cell-mediated lympholysis response to a maternally transmitted antigen.. J Exp Med 1 December 1982; 156 (6): 1866–1871. doi: https://doi.org/10.1084/jem.156.6.1866
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