Two hapten-inhibitable murine monoclonal antiidiotopic antibodies identified two idiotopes expressed by the heavy chain of hybridoma protein 36-65, whose amino acid sequence is encoded in the germ line of A/J mice. Among cross-reactive idiotype-positive hybridoma proteins and p-azophenylarsonate-immune antibodies, the two idiotopes were not always expressed together; some diversified antibodies expressed one idiotope without the other. Suppression that was induced by the two antiidiotopes was idiotope specific and corresponded to the fine specificities of these two reagents.
Fine specificity of idiotope suppression in the A/J anti-azophenylarsonate response.
T L Rothstein, M N Margolies, M L Gefter, A Marshak-Rothstein; Fine specificity of idiotope suppression in the A/J anti-azophenylarsonate response.. J Exp Med 1 February 1983; 157 (2): 795–800. doi: https://doi.org/10.1084/jem.157.2.795
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