The data presented in this paper show that the population of cells that adoptively transfer contact hypersensitivity are Lyt-1+ 2-, I-J- and nonadherent to V. villosa lectin. However, the adoptive transfer of immunity by this population of cells is successful only when the recipient has been treated in such a way as to impair the host immunosuppression mechanism. This population cannot, on its own, transfer immunity to adult, untreated naive recipients unless an additional population of immunoregulatory cells is present. This immunoregulatory population does not itself adoptively transfer immunity. This latter population is differentiated from the immune cells in that they are Lyt-1+ 2-, I-J+ and are adherent to V. villosa lectin. Both populations are required to adoptively transfer immunity to adult untreated naive recipients.
Article| September 01 1983
Role of contrasuppression in the adoptive transfer of immunity.
D R Green
R K Gershon
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1983) 158 (3): 982–987.
M Iverson, W Ptak, D R Green, R K Gershon; Role of contrasuppression in the adoptive transfer of immunity.. J Exp Med 1 September 1983; 158 (3): 982–987. doi: https://doi.org/10.1084/jem.158.3.982
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