In the presence of the soluble polypeptide antigens ovalbumin and keyhole limpet hemocyanin, purified mouse spleen dendritic cells induce the secretion of IL-2 by antigen-specific T cell hybridomas. This response is H-2 restricted and can be specifically inhibited by monoclonal anti-I-A. These data indicate that dendritic cells can present soluble antigen to H-2-compatible T cells.
Mouse spleen dendritic cells present soluble antigens to antigen-specific T cell hybridomas.
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G H Sunshine, D P Gold, H H Wortis, P Marrack, J W Kappler; Mouse spleen dendritic cells present soluble antigens to antigen-specific T cell hybridomas.. J Exp Med 1 November 1983; 158 (5): 1745–1750. doi: https://doi.org/10.1084/jem.158.5.1745
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