Human alloreactive proliferating T cell clones have been compared for their capacity to provide help for B cell activation and the generation of a specific cytotoxic response. The results demonstrate that, when triggered by the relevant alloantigen, the same T cell clone can induce a strong polyclonal B cell activation and serve as the only source of helper cells for the generation of a specific cytotoxic response by any source of CTL precursors against any stimulator cell present in culture.
The same human alloreactive T cell clone can help both B lymphocytes and specific cytotoxic precursors.
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D Ramarli, B Parodi, M Fabbi, G Corte, A Lanzavecchia; The same human alloreactive T cell clone can help both B lymphocytes and specific cytotoxic precursors.. J Exp Med 1 January 1984; 159 (1): 318–323. doi: https://doi.org/10.1084/jem.159.1.318
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