Two-color fluorescence analysis revealed that Tac antigen, which was previously reported to be restricted to T cells, was expressed on a proportion of normal B cells activated by Staphylococcus aureus Cowan I (SAC). Immunoaffinity-purified interleukin 2 (IL-2) induced the proliferation of SAC-activated B cells, and the proliferation was completely inhibited by anti-Tac antibody, which blocked the membrane binding and action of IL-2. These results suggest that an IL-2 receptor system is directly involved in the B cell immune response.
Article| August 01 1984
Expression of Tac antigen on activated normal human B cells.
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1984) 160 (2): 612–617.
M Tsudo, T Uchiyama, H Uchino; Expression of Tac antigen on activated normal human B cells.. J Exp Med 1 August 1984; 160 (2): 612–617. doi: https://doi.org/10.1084/jem.160.2.612
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