Pilocarpine-induced saliva of the tick, Ixodes dammini, inhibited platelet aggregation triggered by ADP and collagen, as well as platelet-aggregation factor. In addition, we found apyrase activity (which degrades ATP and ADP to AMP and orthophosphate) and an anticoagulant. We showed the presence of prostaglandin E2 (PGE2) by bioassay and radioimmunoassay. This saliva inhibited interleukin 2 production by T cell hybridomas, an activity consistent with that of PGE2. A kininase was demonstrated, and this may counteract the algesia- and edema-promoting properties of PGE2. Together, these salivary components produce antihemostatic, antiinflammatory, and immunosuppressive effects that may facilitate feeding, as well as transmission of tick-borne pathogens.
Article|
February 01 1985
Antihemostatic, antiinflammatory, and immunosuppressive properties of the saliva of a tick, Ixodes dammini.
J M Ribeiro
G T Makoul
J Levine
D R Robinson
A Spielman
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1985) 161 (2): 332–344.
Citation
J M Ribeiro, G T Makoul, J Levine, D R Robinson, A Spielman; Antihemostatic, antiinflammatory, and immunosuppressive properties of the saliva of a tick, Ixodes dammini.. J Exp Med 1 February 1985; 161 (2): 332–344. doi: https://doi.org/10.1084/jem.161.2.332
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