The proliferative responses of purified leukemic human B cells from nine B cell chronic lymphocytic leukemias to recombinant interleukin 2 (IL-2), spontaneously, and after preactivation by Staphylococcus aureus Cowan I (SAC) or anti-mu antibodies were studied. Three patterns of response were observed: (a) no response (three cases); (b) a moderate spontaneous response enhanced by anti-mu (one case); (c) a high proliferative response after preactivation by anti-mu and/or SAC (five cases). IL-2 could also trigger normal B cells, purified from spleen, to proliferative after preactivation by anti-mu or SAC. These results provide evidence that IL-2 is a lymphokine that acts physiologically on both B and T cells.
Article| May 01 1985
Interleukin 2-induced proliferation of leukemic human B cells.
J P Fermand
J C Brouet
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1985) 161 (5): 1225–1230.
O Lantz, C Grillot-Courvalin, C Schmitt, J P Fermand, J C Brouet; Interleukin 2-induced proliferation of leukemic human B cells.. J Exp Med 1 May 1985; 161 (5): 1225–1230. doi: https://doi.org/10.1084/jem.161.5.1225
Download citation file: