When cultured human monocytes (MO) were spread on fibronectin (Fn)-coated surfaces, C3 receptors on the MO exhibited markedly enhanced capacity to promote phagocytosis. The activation of C3 receptors by Fn was mediated by a receptor that recognizes a sequence, Arg-Gly-Asp-Ser (RGDS), present in the cell-binding domain of Fn. Soluble, RGDS-containing peptides inhibited the activation of C3 receptors caused by surface-bound Fn, and surface-bound, RGDS-containing peptides themselves caused activation of the C3 receptors of attached MO. Although soluble, RGDS-containing peptides bound to Fn receptors, such monovalent ligation was insufficient to activate C3 receptors.
Article| August 01 1985
Fibronectin receptor of human macrophages recognizes the sequence Arg-Gly-Asp-Ser.
S D Wright
B C Meyer
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1985) 162 (2): 762–767.
S D Wright, B C Meyer; Fibronectin receptor of human macrophages recognizes the sequence Arg-Gly-Asp-Ser.. J Exp Med 1 August 1985; 162 (2): 762–767. doi: https://doi.org/10.1084/jem.162.2.762
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