We describe here a monoclonal antibody, 131, which appears to recognize a determinant shared by HLA-A locus-encoded gene products. Isoelectric focusing analysis demonstrates that 131 reacts with the products of at least seven different HLA-A alleles but none of the five HLA-B allelic products tested. Together with evidence provided by other studies, this finding indicates the existence of A-unique and B-unique determinants, which may have different biological functions. Monoclonal antibody probes, such as the one described here, specific for shared intralocus determinants, may be valuable for assessing these possible functional differences.

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