Intraperitoneal administration of group A streptococcal cell walls to Lewis rats induces a chronic arthritis, whereas the Fischer strain is resistant to the development of the lesion. Spleen cells from cell wall-treated rats (Lewis and Fischer) are deficient in the synthesis of IL-2. Using an mAb directed against the rat IL-2-R, the present studies indicate that the expression of IL-2-R on spleens of cell wall-treated rats is normal. However, the addition of exogenous IL-2 to spleen cells cultured with Con A does not stimulate the mitogenic response.
Administration of group A streptococcal cell walls to rats induces an interleukin 2 deficiency.
S C Ridge, J B Zabriskie, H Osawa, T Diamantstein, A L Oronsky, S S Kerwar; Administration of group A streptococcal cell walls to rats induces an interleukin 2 deficiency.. J Exp Med 1 July 1986; 164 (1): 327–332. doi: https://doi.org/10.1084/jem.164.1.327
Download citation file: