Mutational mechanisms operating at the T cell receptor beta chain locus have been examined by comparison of the CT beta 1 and CT beta 2 gene sequences from Mus pahari, believed to be the oldest living species in the genus Mus, with those of inbred mice. Results indicate that a gene correction event independent of that suggested to have occurred in inbred mice has homogenized the M. pahari CT beta exon 1 sequences, minimizing diversity in this region of the molecule. These observations suggest that correction events such as gene conversion may occur frequently, even in pauci-gene families with as few as two members, and therefore play a significant role in gene diversification or homogenization of small as well as large gene families.
Article| December 01 1986
Gene correction in the evolution of the T cell receptor beta chain.
Online Issn: 1540-9538
Print Issn: 0022-1007
J Exp Med (1986) 164 (6): 2083–2088.
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E Jouvin-Marche, M Heller, S Rudikoff; Gene correction in the evolution of the T cell receptor beta chain.. J Exp Med 1 December 1986; 164 (6): 2083–2088. doi: https://doi.org/10.1084/jem.164.6.2083
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