This study demonstrates a profound elevation of NK activity, as measured by cytotoxicity to YAC-1 targets in a 4-h incubation 51Cr-release assay, of freshly isolated hepatic NPC from both MRL/lpr and (NZB X NZW)F1 mice. This marked increase was not observed in splenic or peripheral blood NK. The hepatic NK were nonadherent, radioresistant, Ly-1-,2-, and AGM1+. Furthermore, biologic response modifiers can further augment hepatic NK activity in these autoimmune strains.
Article| July 01 1987
High hepatic natural killer cell activity in murine lupus.
D B Magilavy
A D Steinberg
S L Latta
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1987) 166 (1): 271–276.
D B Magilavy, A D Steinberg, S L Latta; High hepatic natural killer cell activity in murine lupus.. J Exp Med 1 July 1987; 166 (1): 271–276. doi: https://doi.org/10.1084/jem.166.1.271
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