B cells from patients suffering from B-type chronic lymphocytic leukemia (B-CLL) are susceptible to the effects of several interleukins. Using the cells from 12 different patients we show that IL-4 does not synergize with anti-mu antibody for the enhancement of DNA synthesis. Moreover IL-4 profoundly (90%) suppresses the response to IL-2 in the 10 patient responders to this interleukin. This suppression occurs whether IL-2 is used alone, in costimulation with anti-mu antibody, or in synergy with IFN-gamma. In no instance did IL-4 induce terminal differentiation. This negative effect of IL-4 can take place in monoclonal B-CLL cells where IL-4 enhances the expression of CD23. IL-4 does not interfere with the upregulation of CD25 by IL-2. Thus, IL-4 may display inhibitory effects on the proliferative response of selected B cell populations. The antagonism between IL-4 and IL-2 has important implications for the potential use of cytokines in the management of B-CLL patients.
Article|
July 01 1988
Interleukin 4 counteracts the interleukin 2-induced proliferation of monoclonal B cells.
S Karray,
S Karray
Institut National de la Recherche Scientifique, Unité 131, Clamart, France.
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T DeFrance,
T DeFrance
Institut National de la Recherche Scientifique, Unité 131, Clamart, France.
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H Merle-Béral,
H Merle-Béral
Institut National de la Recherche Scientifique, Unité 131, Clamart, France.
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J Banchereau,
J Banchereau
Institut National de la Recherche Scientifique, Unité 131, Clamart, France.
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P Debré,
P Debré
Institut National de la Recherche Scientifique, Unité 131, Clamart, France.
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P Galanaud
P Galanaud
Institut National de la Recherche Scientifique, Unité 131, Clamart, France.
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S Karray
Institut National de la Recherche Scientifique, Unité 131, Clamart, France.
T DeFrance
Institut National de la Recherche Scientifique, Unité 131, Clamart, France.
H Merle-Béral
Institut National de la Recherche Scientifique, Unité 131, Clamart, France.
J Banchereau
Institut National de la Recherche Scientifique, Unité 131, Clamart, France.
P Debré
Institut National de la Recherche Scientifique, Unité 131, Clamart, France.
P Galanaud
Institut National de la Recherche Scientifique, Unité 131, Clamart, France.
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1988) 168 (1): 85–94.
Citation
S Karray, T DeFrance, H Merle-Béral, J Banchereau, P Debré, P Galanaud; Interleukin 4 counteracts the interleukin 2-induced proliferation of monoclonal B cells.. J Exp Med 1 July 1988; 168 (1): 85–94. doi: https://doi.org/10.1084/jem.168.1.85
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