Immunization of two cynomolugus and three rhesus monkeys with purified type II collagen resulted in the development of polyarthritis. Arthritis first became clinically apparent 7 wk after primary immunization and persisted for 16 mo. Radiologic examination of the limbs demonstrated soft tissue swelling with severe joint destruction including loss of cartilage and bone. Involved joints eventually became ankylosed with permanent loss of some motion. All of the monkeys developed a response to the immunizing collagen as determined by ELISA of serum for antibodies. Arthritis was associated with weight loss and constitutional symptoms, including lethargy and refusal to eat. One monkey became so debilitated that it was necessary to euthanize it. Histologic examination of the joints showed synovial hypertrophy with pannus formation. A control monkey immunized with type I collagen suffered no apparent ill effects.
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August 01 1988
Induction of arthritis in monkeys by immunization with type II collagen.
T J Yoo,
T J Yoo
Department of Medicine, University of Tennessee, Veterans Administration Medical Center, Memphis 38163.
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S Y Kim,
S Y Kim
Department of Medicine, University of Tennessee, Veterans Administration Medical Center, Memphis 38163.
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J M Stuart,
J M Stuart
Department of Medicine, University of Tennessee, Veterans Administration Medical Center, Memphis 38163.
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R A Floyd,
R A Floyd
Department of Medicine, University of Tennessee, Veterans Administration Medical Center, Memphis 38163.
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G A Olson,
G A Olson
Department of Medicine, University of Tennessee, Veterans Administration Medical Center, Memphis 38163.
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M A Cremer,
M A Cremer
Department of Medicine, University of Tennessee, Veterans Administration Medical Center, Memphis 38163.
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A H Kang
A H Kang
Department of Medicine, University of Tennessee, Veterans Administration Medical Center, Memphis 38163.
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T J Yoo
Department of Medicine, University of Tennessee, Veterans Administration Medical Center, Memphis 38163.
S Y Kim
Department of Medicine, University of Tennessee, Veterans Administration Medical Center, Memphis 38163.
J M Stuart
Department of Medicine, University of Tennessee, Veterans Administration Medical Center, Memphis 38163.
R A Floyd
Department of Medicine, University of Tennessee, Veterans Administration Medical Center, Memphis 38163.
G A Olson
Department of Medicine, University of Tennessee, Veterans Administration Medical Center, Memphis 38163.
M A Cremer
Department of Medicine, University of Tennessee, Veterans Administration Medical Center, Memphis 38163.
A H Kang
Department of Medicine, University of Tennessee, Veterans Administration Medical Center, Memphis 38163.
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1988) 168 (2): 777–782.
Citation
T J Yoo, S Y Kim, J M Stuart, R A Floyd, G A Olson, M A Cremer, A H Kang; Induction of arthritis in monkeys by immunization with type II collagen.. J Exp Med 1 August 1988; 168 (2): 777–782. doi: https://doi.org/10.1084/jem.168.2.777
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