By using mAb and flow cytometry, a constitutive expression of the p75 IL-2R was revealed in human peripheral blood CD8+ T cells and TCR delta-1+ T cells as well as in CD16+ NK cells. Anti-p75 IL-2R mAb almost completely inhibited the induction of cytolytic activity in these T cells by brief exposure to IL-2, as estimated by anti-TCR/CD3 mAb-targeted cytotoxicity. While anti-p55 IL-2R mAb alone inhibited the response only modestly, maximal inhibition was achieved by combining both anti-p55 and anti-p75 IL-2R mAbs. These results indicate that the p75 IL-2R constitutively expressed on peripheral blood CD8+ T cells and TCR delta-1+ T cells is predominantly responsible for the direct activation of these cells by IL-2.
Activation of peripheral blood T cells via the p75 interleukin 2 receptor.
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H Yagita, M Nakata, A Azuma, T Nitta, T Takeshita, K Sugamura, K Okumura; Activation of peripheral blood T cells via the p75 interleukin 2 receptor.. J Exp Med 1 October 1989; 170 (4): 1445–1450. doi: https://doi.org/10.1084/jem.170.4.1445
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