The role of B cells in induction of phenotypic and functional abnormalities of T cells in a murine retrovirus-induced immunodeficiency syndrome, MAIDS, was evaluated in mice depleted of mature B cells from birth with anti-IgM antibodies (mu-suppressed) and infected at 4 wk of age. Multicolor FACS analyses of CD4+ T cell subsets showed that development of phenotypic abnormalities of these cells at 9 wk after infection was completely inhibited by mu-suppression. Furthermore, induction of impaired proliferative responses to Con A and alloantigens and CTL responses to alloantigens was fully blocked in antibody-treated animals. The extent of virus replication was comparable in spleens of untreated and mu-suppressed mice. Retroviral induction of T cell dysfunction in MAIDS is thus dependent on the presence of B cells, and high level virus expression in mice without B cells has little or no effect on T cell function.
B cells are required for induction of T cell abnormalities in a murine retrovirus-induced immunodeficiency syndrome.
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A Cerny, A W Hügin, R R Hardy, K Hayakawa, R M Zinkernagel, M Makino, H C Morse; B cells are required for induction of T cell abnormalities in a murine retrovirus-induced immunodeficiency syndrome.. J Exp Med 1 January 1990; 171 (1): 315–320. doi: https://doi.org/10.1084/jem.171.1.315
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